Inter-arm differences in blood pressure (IAD) are associated with increased cardiovascular and all-cause mortality in various cohort studies. INTERPRESS is an individual patient data (IPD) meta-analysis to address questions arising from previous work:
- What is the independent contribution of IAD to prognostic risk estimation for cardiovascular and all-cause mortality?
- What minimum cut-off value for IAD defines elevated risk?
- What is the incremental association between IAD and mortality risk?
- Do different IAD measurement techniques affect the prognostic value of IAD measurements?
An international collaboration, the INTERPRESS-IPD, was formed to address these questions by combining individual patient data from IAD cohort studies into a single large dataset for IPD meta-analysis. Three public advisors were involved in this collaboration to offer their perspective on the development and conduct of the research.
To give a brief outline of the meta-analysis then, in more detail, describe how three public advisors were involved in INTERPRESS and explore the impact of their involvement on the research process, on the researchers and on the public advisors. We will also explore what factors enabled the public advisors to express their views openly within the research process.
The participants in this study, on the impact of involvement in INTERPRESS, are the 11 members of the INTERPRESS international collaboration, the three public advisors and the three external members of the independent monitoring group. The presentation will draw on inductive and thematic analysis of transcribed audio recordings of the meetings (n = 12).
Findings and conclusions:
The qualitative research data collection completes in April 2018. We will present results from our full analysis, which will be conducted in May, June and July 2018. Ongoing feedback and reflections on the involvement has been gathered throughout the study's life-course, drawing on the PiiAF framework.
Patient or healthcare consumer involvement:
This research explores how public involvement impacted an IPD meta-analysis. This abstract has been co-produced with the INTERPRESS public advisors and and we will co-present the results.